Aortic Root Dynamics 1, 3
Does not create additional rigidity in the aortic root and is designed to avoid a stenosing effect, similar to frameless bioprosthesis behavior.
ADVALVE ULTRA
BIOPROSTHETIC AORTIC VALVE
A Lifetime of Confidence.
ADVALVE ULTRA is a new generation bovine pericardial semi-framed bioprosthesis, combining the superior haemodynamic performance of a stentless design with the implantation ease of a stented platform. Its superelastic nitinol wire form simulates natural biomechanics through the cardiac cycle, while aldehyde-free EGDGE fixation reduces calcium-binding potential and enables additional antithrombotic, antibacterial, and anti-calcification treatment.
ADVALVE Design & Engineering
Super Elastic
Nitinol Wire Form
Bovine
Pericardium Leaflets
Bovine
Pericardium Rim
Replicating Nature.
Redefining Performance.
- A new generation bovine pericardial semi-framed bioprosthesis, combining superior
- haemodynamic performance of a stentless design, & implantation ease of a stented platform.
Key Design Advantages
Procedural Efficiency 1, 2
Facilitates easier intra-operative manipulation, designed to help reduce the duration of the aortic cross-clamp.
Single-seam Implantation2,3
Integrated wire frame establishes a clear structural boundary, supporting a straightforward forward single-seam technique.
Simulated Biomechanics 2
Flexible nitinol frame designed to simulate natural biomechanical characteristics during the cardiac cycle.
Replicating Nature.
Redefining Performance.
Super Elastic
Nitinol Wire Form
Bovine
Pericardium Leaflets
Bovine
Pericardium Rim
Replicating Nature.
Redefining Performance.
- A new generation bovine pericardial semi-framed bioprosthesis, combining superior
- haemodynamic performance of a stentless design, & implantation ease of a stented platform.
Key Design Advantages
Key Design Advantages
Aortic Root Dynamics 1, 3
Does not create additional rigidity in the aortic root and is designed to avoid a stenosing effect, similar to frameless bioprosthesis behavior.
Procedural Efficiency 1, 2
Facilitates easier intra-operative manipulation, designed to help reduce the duration of the aortic cross-clamp.
Single-seam Implantation2,3
Integrated wire frame establishes a clear structural boundary, supporting a straightforward forward single-seam technique.
Simulated Biomechanics 2
Flexible nitinol frame designed to simulate natural biomechanical characteristics during the cardiac cycle.
EGDGE Compound 97% PURITY
EGDGE reduces calcium-binding potential during basic fixation, facilitating additional antithrombotic, antibacterial, and anti-calcification treatment.
LMWH
Covalent binding designed to reduce platelet adhesion & aggregation, enhancing hemocompatibility
Anti-Calcium
Diphosphonates applied to inhibit the conversion of calcium phosphate into rigid hydroxyapatite deposits
Anti-Bacterial
Chlorhexidine bigluconate film intended to provide broad-spectrum protection against microorganisms
EGDGE Fixation
Long Term Clinical Outcome At 9 Years4
78%Freedom From Calcification
74%Freedom From Primary Tissue Failure
In this Russian multicenter study from 1991-2005; 1,060 valves, including 713 in the mitral position, were implanted. Average age of patients was 49 years, volume of follow up was 108 patient years, and completeness was 61%.
References
1.
Evtushenko A.V Et Al: The Results Of The Long-Term Isolated Use Of Xenopericardial Bioprosthesis Of The New Generation TiAra In The Long-Term Period: Clinical And Experimental Surgery. Petrovsky Journal Volume 11. No. 1. 2023.
2.
Evtushenko A.V. Et.Al: First Clinical Experience Of The Implantation Of The New Generation Xenopericardial Semi-Framed Bioprosthesis TiAra. Clinical And Experimental Surgery. Petrovsky Journal. 2021; 9 (2):
3.
Rf Patent No. 2355361 Cl. A61F 2/24, Published On 05/20/2009.
4.
Astapov D. A Et.Al: Experimental And Clinical Substantiation Of Implantation Efficacy In The Aortic Position Of “Tiara” Bioprosthesis With A Stent Made Of Nitinol: Complex Issues Of Cardiovascular Diseases, 2013 No 4
5.
Bioprosthetic Heart Valves In Russia: Experience Of Three Clinics / L. S. Barbarash [Et Al.] // Pathologia Circulationis Et Cardiosirurgia. 2011. No. 2. P. 21-26.