Advalve
Biological Heart Valve Prosthesis
Let Life Endure.
ADVALVE Bioprosthesis is made of bovine pericardial leaflets, shaped using advanced digital fabrication to ensure precise edge integrity and uniform thickness for consistent performance and durability. It features a compound stent combining polypropylene and superelastic shape-memory alloy, delivering structural stability and adaptive fit within the native anatomy.
ADVALVE Design & Engineering
Sewing Cuff
Polypropylene
Frame Base
Nitinol Ring
Sewing Holes
Nitinol Wire Frame
Spatial Modeling Technology
Composite Metal Polymer Stent 1, 2
- Redistributes significant load to the polymer frame.
- The Nitinol wire circuit acts as a vibration dampener.
Advanced Leaflet Technology
Advanced Digital Fabrication
- Pericardial thickness detection ensures uniform prosthesis quality.
- Even stress distribution across leaflet surface.
Spatial Modeling Technology
Sewing Cuff
Polypropylene
Frame Base
Nitinol Ring
Sewing Holes
Nitinol Wire Frame
Spatial Modeling Technology
Composite Metal Polymer Stent 1, 2
- Redistributes significant load to the polymer frame.
- The Nitinol wire circuit acts as a vibration dampener.
Advanced Leaflet Technology
Advanced Leaflet Technology
Advanced Digital Fabrication
- Pericardial thickness detection ensures uniform prosthesis quality.
- Even stress distribution across leaflet surface.
EGDGE Treatment is a biological tissue fixation technology that uses ethylene glycol diglycidyl ether (EGDGE) to crosslink collagen structures in bioprosthetic materials. Unlike traditional glutaraldehyde fixation, EGDGE preserves collagen's natural structure, reduces calcium-binding (thus lowering calcification risk), and enhances the biomechanical, hemocompatibility, and biocompatibility properties of the biomaterial, improving long-term clinical outcomes for cardiovascular implants
Tissue Fixation Technology
Designed for seamless integration and stable anchoring.
Lower Calcification Risk
Advanced biomaterials for reduced mineral deposition over time.
Enhanced Elasticity and Durability
Maintains mechanical integrity through millions of cardiac cycles.
Resistant to Long-Term Degradation
Built to endure, even in the most demanding physiological environments.
Antibacterial Treatment
Embedded protection to help guard against postoperative infections.
Tissue Fixation Technology
EGDGE Cross-Linking Minimizes Calcification.
Fig.1 - Accumulation of calcium in biomaterial implanted in animals (accelerated calcification model). Next to the name of the fixative is a diagram of its molecule, where the hydrocarbon chain; reaction groups . At point “0” is the amount of calcium in the non-implanted biomaterial.3
Biomechanical Characteristics
Enhanced Elasticity and Durability, Resistant to Long-Term Degradation.
Fig.2 - PV - Porcine Aortic Valve Leaflets, P - Pericardium, C- Cattle Arteries3
ADVALVEAortic
A Legacy of Trust
ADVALVE Aortic is a stented bovine pericardial valve designed for supra-annular implantation in the aortic position, combining advanced material treatment, precision engineering, and a flexible stent structure to ensure durability, ease of implantation, and long-term performance.
Absence of Structural Degeneration
Using ADVALVE to treat isolated aortic valve defect demonstrates low risk of structural prosthesis degeneration within 10 years of follow-up.
Longterm Durability
Patient Survival & Valve Performance
Freedom from Valve Deterioration
Patient Survival & Valve Performance
Technical Specification
ADVALVE Aortic is a stented bovine pericardial valve designed for supra-annular implantation in the aortic position, combining advanced material treatment, precision engineering, and a flexible stent structure to ensure durability, ease of implantation, and long-term performance.
Absence of Structural Degeneration
Using ADVALVE to treat isolated aortic valve defect demonstrates low risk of structural prosthesis degeneration within 10 years of follow-up.
Longterm Durability
Patient Survival & Valve Performance
Freedom from Valve Deterioration
Patient Survival & Valve Performance
Freedom from Valve Deterioration
Technical Specification
ADVALVEMitral
A Legacy of Trust
ADVALVE Mitral is a stented xenopericardial valve designed for supra-annular implantation in the mitral position, featuring an advanced frame structure and precision-engineered bovine pericardial leaflets to ensure durability, surgical ease, and long-term clinical performance.
Absence of Structural Degeneration
Kaplan-Meier analysis for absence of structural prosthesis degeneration in ADVALVE Atrioventricular prosthesis recipients
Longterm Durability
Engineered for Long-Term Confidence
Reliable. Resilient. Remarkable.
In patients aged 65 and above, the ADVALVE bioprosthesis demonstrates a high survival rate by the 05 years - on par with leading Western analogs.
Exceptional Clinical Safety
At 6 years, ADVALVE offers natural remodeling, reduced pulmonary pressure, and eliminates the need for synthetic components, making it an ideal choice for patients with limited anticoagulation compliance.
Engineered for Long-Term Confidence
Technical Specification
ADVALVE Mitral is a stented xenopericardial valve designed for supra-annular implantation in the mitral position, featuring an advanced frame structure and precision-engineered bovine pericardial leaflets to ensure durability, surgical ease, and long-term clinical performance.
Absence of Structural Degeneration
Kaplan-Meier analysis for absence of structural prosthesis degeneration in ADVALVE Atrioventricular prosthesis recipients
Longterm Durability
Engineered for Long-Term Confidence
Reliable. Resilient. Remarkable.
In patients aged 65 and above, the ADVALVE bioprosthesis demonstrates a high survival rate by the 05 years - on par with leading Western analogs.
Exceptional Clinical Safety
At 6 years, ADVALVE offers natural remodeling, reduced pulmonary pressure, and eliminates the need for synthetic components, making it an ideal choice for patients with limited anticoagulation compliance.
Engineered for Long-Term Confidence
Bleeding-Free
Thromboembolism Free
Exceptional Clinical Safety
Technical Specification
References
- Karaskov, A. M., et al. "Uniline Next-Generation Russian Biological Prosthesis for Mitral Valve Replacement: First Experience." Paper presented at: Russian Journal of Thoracic and Cardiovascular Surgery Conference, 1–6 Feb. 2017, Russia.
- Barbarash, L. S., and I. Y. Zhuravleva. "Evolution of Heart Valve Bioprostheses: Achievements and Challenges of Two Decades." Paper presented at: Scientific Research Institute of Complex Problems of Cardiovascular Diseases, 2012, Kemerovo, Russia .
- Data on file.
** ADVALVE is manufactured by AMS under a technology license from Neocor for Uniline.