ADVALVE Biological Heart Valve Prosthesis
Advanced Engineering That Stays True to Surgical Needs for Natural Heart Valve Replacement
In the evolving landscape of cardiac surgery, ADVALVE™—our ALDEHYDE-FREE biological heart valve—is redefining standards for durability, hemodynamic efficiency, and patient safety. As cardiac surgeons and hospitals seek valve prostheses that blend natural tissue performance with structural resilience, we proudly introduce ADVALVE™, a next-generation biological heart valve prosthesis engineered with grounded, reliable performance and patient-centered outcomes.
Together with our Mitral TriSync Implant System, ADVALVE™ advances aortic and mitral valve replacement (AVR & MVR) into a new era of surgical excellence.
Advanced Engineering: Spatial Modeling Technology
At the heart of ADVALVE™ is our Spatial Modeling Technology, which incorporates a Composite Metal Polymer Stent—a unique blend of polypropylene base and Nitinol wire frame.
- The Nitinol ring acts as a vibration dampener, improving fatigue resistance and reducing stress concentration on the frame.
- The metal-polymer integration redistributes significant load across the structure, reducing mechanical degradation over time.
- The anatomical frame includes precise sewing holes and a flexible sewing cuff, making the valve intuitive to implant across a variety of surgical techniques—including minimally invasive cardiac surgery.
This optimized structure enables ease of implantation, robust anchoring, and long-term mechanical performance.
Digital Precision: Advanced Leaflet Technology
ADVALVE™ employs Advanced Digital Fabrication to ensure every valve leaflet delivers consistent performance. Our digital processing detects pericardial thickness across the tissue, selecting only uniform zones to manufacture the valve.
This results in:
- Uniform leaflet stress distribution, minimizing wear and tear.
- 100% leaflet coaptation without compromise.
- Enhanced symmetry, contributing to optimized blood flow across the valve orifice.
This innovation supports a long-lasting, smooth hemodynamic profile, reducing the risk of regurgitation and valve failure.
EGDGE™ Tissue Fixation Technology: Defending Against Calcification
Tissue integrity is central to valve performance. ADVALVE™ integrates EGDGE (Ethylene Glycol Diglycidyl Ether) technology—an advanced cross-linking method that stabilizes the bovine pericardium without compromising flexibility.
Key Benefits:
✅ Effective Inhibition of Calcification
✅ Long-Term Protection
✅ Antibacterial Protection
Biomechanical Characteristics: Built to Endure
ADVALVE™ is validated for enhanced elasticity and structural durability, resisting degradation over years of cyclic cardiac stress. Whether used in high-pressure aortic positions or the more delicate mitral position, the valve maintains its anatomical shape and leaflet function.
Mitral Valve: With the TriSync™ Implant System
For mitral valve replacement (MVR), precise alignment and fixation are critical. The Mitral TriSync Implant System is designed to complement ADVALVE™ in mitral applications, offering:
- Three-point fixation for enhanced anchoring and annular remodeling.
- Symmetric stress distribution, helping preserve valve geometry.
ADVALVE™ in Clinical Practice
- Easy handling and quick deployment
- Compatibility with standard surgical sutures
- Pre-mounted delivery system for time efficiency
- Reliable coaptation and flow dynamics
References
* Karaskov, A. M., et al. “Uniline Next-Generation Russian Biological Prosthesis for Mitral Valve Replacement: First Experience.” Paper presented at: Russian Journal of Thoracic and Cardiovascular Surgery Conference, 1–6 Feb. 2017, Russia.
* Barbarash, L. S., and I. Y. Zhuravleva. “Evolution of Heart Valve Bioprostheses: Achievements and Challenges of Two Decades.” Paper presented at: Scientific Research Institute of Complex Problems of Cardiovascular Diseases, 2012, Kemerovo, Russia .
* Data on file. ** ADVALVE is manufactured by AMS under a technology license from Neocor for Uniline.